Semaglutide is part of a class of drugs known as GLP-1 receptor agonists. These medications are commonly prescribed for the management of type 2 diabetes and, in some cases, for weight loss. Like all medications, GLP-1 receptor agonists can have side effects.

It's important to talk to a healthcare provider to weigh the benefits and risks of any GLP-1 medication, especially if you have a history of thyroid, pancreas, kidney, or gallbladder issues.

Here are the common and serious side effects associated with these medications:

Common Side Effects:

1. **Nausea** – Often seen when starting treatment, but it usually decreases over time.

2. **Diarrhea** – Gastrointestinal discomfort is common, particularly in the first few weeks.

3. **Vomiting** – Can occur, especially when the dose is increased.

4. **Constipation** – Some patients report difficulty with bowel movements.

5. **Abdominal pain** – Mild to moderate discomfort in the stomach area.

6. **Decreased appetite** – These drugs can reduce hunger, which is sometimes a desired effect in weight management.

7. **Fatigue** – Feeling more tired than usual can occur.

8. **Dyspepsia (indigestion)** – Heartburn or a sensation of fullness may be experienced.

Serious Side Effects:

1. **Pancreatitis** – Inflammation of the pancreas is rare but can occur. Symptoms include severe stomach pain that may radiate to the back, nausea, and vomiting.

2. **Kidney problems** – Dehydration from vomiting or diarrhea can lead to kidney issues.

3. **Hypoglycemia (low blood sugar)** – More likely if used with insulin or other diabetes medications, causing shakiness, dizziness, sweating, or confusion.

4. **Thyroid tumors** – Studies in animals have shown a potential increased risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC). While the risk in humans is not well established, people with a personal or family history of MTC or multiple endocrine neoplasia syndrome type 2 (MEN 2) should avoid GLP-1 agonists.

5. **Gallbladder disease** – There is a small risk of gallstones or gallbladder inflammation.

6. **Allergic reactions** – Serious allergic reactions, although rare, can include swelling of the face, lips, tongue, or throat, and difficulty breathing.

Other Possible Side Effects:

- **Increased heart rate** – Some GLP-1 medications can raise your resting heart rate.